Roberts N J, Diamond M E, Douglas R G, Simons R L, Steigbigel R T
J Med Virol. 1980;5(1):17-23. doi: 10.1002/jmv.1890050103.
Human macrophages were exposed to two influenza A viruses representing different subtypes. The donors were likely to have been exposed to one subtype (H3N2) but not to the other (H0N 1). Similar effects upon the macrophages were observed for both subtypes: macrophage enhancement of mitogen-stimulated lymphocyte transformation responses was depressed, and the macrophages produced interferon. In contrast, macrophages exposed to inactivated virus exhibited normal enhancement of lymphocyte transformation response, yet produced interferon, although in lower titers than did macrophages exposed to infectious virus.
将人类巨噬细胞暴露于两种代表不同亚型的甲型流感病毒。供体可能已接触过一种亚型（H3N2），但未接触过另一种亚型（H0N1）。两种亚型对巨噬细胞均观察到类似的效应：巨噬细胞对丝裂原刺激的淋巴细胞转化反应的增强作用受到抑制，且巨噬细胞产生干扰素。相比之下，暴露于灭活病毒的巨噬细胞对淋巴细胞转化反应表现出正常的增强作用，也产生干扰素，不过其滴度低于暴露于感染性病毒的巨噬细胞。
