人单核白细胞产生干扰素：呼吸道合胞病毒与流感病毒之间的差异。
Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses.
作者信息
Chonmaitree T, Roberts N J, Douglas R G, Hall C B, Simons R L
出版信息
Infect Immun. 1981 Apr;32(1):300-3. doi: 10.1128/iai.32.1.300-303.1981.
Abstract
The ability of respiratory syncytial virus (RSV) to induce interferon production by human mononuclear leukocytes was compared with that of influenza viruses. Cell culture fluids were assayed for interferon activity 1, 3 and 7 days after exposure to RSV or to one of two subtypes of influenza A virus (H0N1 and H3N2). RSV induced interferon production inconsistently and in low titers. Varying the multiplicity of infection did not improve the ability of RSV to induce interferon production. In contrast, influenza viruses were effective inducers of interferon production. Seropositivity to the influenza virus strains was not associated with increased interferon titers. Interferon produced after exposure to RSV or to the influenza viruses was resistant to low pH treatment. The data suggest that interferon production may not be a major component of human immunological defense against RSV infection.
摘要
将呼吸道合胞病毒（RSV）与人单核白细胞诱导干扰素产生的能力与流感病毒进行了比较。在暴露于RSV或两种甲型流感病毒亚型（H0N1和H3N2）之一后的1、3和7天，对细胞培养液进行干扰素活性检测。RSV诱导干扰素产生的情况不一致且效价较低。改变感染复数并未提高RSV诱导干扰素产生的能力。相比之下，流感病毒是干扰素产生的有效诱导剂。对流感病毒株的血清阳性与干扰素效价升高无关。暴露于RSV或流感病毒后产生的干扰素对低pH处理具有抗性。数据表明，干扰素产生可能不是人类针对RSV感染的免疫防御的主要组成部分。
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