右旋糖酐分子量对血链球菌黏附于受损心脏瓣膜的影响。
Effects of molecular weight of dextran on the adherence of Streptococcus sanguis to damaged heart valves.
作者信息
Ramirez-Ronda C H
出版信息
Infect Immun. 1980 Jul;29(1):1-7. doi: 10.1128/iai.29.1.1-7.1980.
Abstract
Dextran-producing streptococci such as Streptococcus sanguis are the organisms most frequently associated with infective endocarditis in humans. A series of experiments was designed to study how the molecular weight of dextrans affects the adherence of an endocarditis strain of S. sanguis to canine heart valves covered with platelets and fibrin. The data indicated that this adherence was dependent on dextrans of high molecular weight, such as dextran T-2000 or glucans isolated from S. sanguis or S. mutans. The adherence properties of the strain studied were not modified by prior exposure of the bacterial cells of valve leaflets to high-molecular-weight dextrans. Preexposure of bacterial cells or valve leaflets to low-molecular-weight dextrans decreased their adherence. Low-molecular-weight dextrans interfered with adherence of dextran-positive strains to damaged heart valves.
摘要
产生葡聚糖的链球菌，如血链球菌，是人类感染性心内膜炎最常涉及的微生物。设计了一系列实验来研究葡聚糖的分子量如何影响血链球菌心内膜炎菌株对覆盖有血小板和纤维蛋白的犬心瓣膜的黏附。数据表明，这种黏附依赖于高分子量的葡聚糖，如葡聚糖T - 2000或从血链球菌或变形链球菌中分离出的葡聚糖。所研究菌株的黏附特性不会因细菌细胞或瓣膜小叶预先暴露于高分子量葡聚糖而改变。细菌细胞或瓣膜小叶预先暴露于低分子量葡聚糖会降低它们的黏附。低分子量葡聚糖会干扰葡聚糖阳性菌株对受损心脏瓣膜的黏附。
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