Rosenthal N E, Davenport Y, Cowdry R W, Webster M H, Goodwin F K
Psychiatry Res. 1980 Mar;2(1):113-9. doi: 10.1016/0165-1781(80)90012-8.
Lumbar punctures were performed on 69 patients who met Research Diagnostic Criteria (RDC) for major affective disorder, while they were drug-free and depressed. None of the patients met RDC for alcoholism. Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by fluorometry and 3-methoxy-4-hydroxyphenylglycol (MHPG) by gas chromatography. Family histories were ascertained by systematic interviews of patients and their relatives, and diagnoses were made by family history diagnostic criteria (Andreasen et al., 1977). Depressed patients with alcoholism in a first degree relative had significantly lower levels of 5-HIAA and MHPG than patients without a family history of alcoholism (p < 0.05). No difference in HVA levels was found. The metabolite differences remained significant when the influence of sex ratio was considered. These results are in agreement with previous work linking alcoholism to abnormal serotonin metabolism. They provide further biochemical evidence of distinct genetic subtypes of affective disorder along lines suggested by Winokur (1979a, 1979b), and illustrate the usefulness of the family history method in defining patient subgroups.
对69名符合重性情感障碍研究诊断标准（RDC）的患者进行了腰椎穿刺，这些患者当时未服用药物且处于抑郁状态。所有患者均不符合酒精中毒的RDC标准。通过荧光法测量脑脊液中的5-羟吲哚乙酸（5-HIAA）和高香草酸（HVA），通过气相色谱法测量3-甲氧基-4-羟基苯乙二醇（MHPG）。通过对患者及其亲属进行系统访谈来确定家族史，并根据家族史诊断标准进行诊断（Andreasen等人，1977年）。一级亲属中有酒精中毒的抑郁症患者，其5-HIAA和MHPG水平显著低于无酒精中毒家族史的患者（p < 0.05）。未发现HVA水平存在差异。在考虑性别比例的影响时，代谢物差异仍然显著。这些结果与先前将酒精中毒与异常血清素代谢联系起来的研究一致。它们为Winokur（1979a，1979b）提出的情感障碍不同遗传亚型提供了进一步的生化证据，并说明了家族史方法在定义患者亚组方面的有用性。
