Bertilsson L, Asberg M, Lantto O, Scalia-Tomba G P, Träskman-Bendz L, Tybring G
Psychiatry Res. 1982 Feb;6(1):77-83. doi: 10.1016/0165-1781(82)90040-3.
Amine metabolites and cortisol were measured in four consecutive 3 ml samples of lumbar cerebrospinal fluid (CSF). There were pronounced concentration gradients for both 5-hydroxyindoleacetic acid and homovanillic acid, and there was no difference in the gradients of 11 controls and 17 psychiatric patients (10 depressed). As there was a close correlation between the mean of the first two fractions and the mean of all four fractions, a concentration obtained in 6 ml can be used to calculate that in a 12 ml CSF sample. In psychiatric patients there was a slight, but statistically significant concentration gradient for 3-methoxy-4-hydroxyphenylglycol (unconjugated as well as conjugated). No gradient was found for cortisol in CSF.
在连续采集的4份3毫升腰椎脑脊液（CSF）样本中测定了胺代谢物和皮质醇。5-羟吲哚乙酸和高香草酸均存在明显的浓度梯度，11名对照者和17名精神科患者（10名抑郁症患者）的梯度无差异。由于前两个样本的均值与全部4个样本的均值密切相关，因此6毫升样本中获得的浓度可用于计算12毫升脑脊液样本中的浓度。在精神科患者中，3-甲氧基-4-羟基苯乙二醇（未结合及结合形式）存在轻微但具有统计学意义的浓度梯度。脑脊液中未发现皮质醇的梯度。
