Poulsen K, Jakobsen B K, Mikkelsen B M, Harmark K, Nielsen J T, Hjorth J P
EMBO J. 1986 Aug;5(8):1891-6. doi: 10.1002/j.1460-2075.1986.tb04441.x.
PSP, parotid secretory protein, and salivary amylase are the major secretory proteins of mouse parotid gland where they appear in a constant ratio. Here we describe the isolation of the PSP gene and show through expression analysis on this and the salivary amylase gene that the two genes are transcribed in a coordinate fashion in adult animals, whereas the activation profiles are different during postnatal development. An explanation is put forward that involves activation of the genes at different stages of the acinar cell differentiation, leading in adults to the maximal and thus proportionate expression.
腮腺分泌蛋白（PSP）、腮腺分泌蛋白和唾液淀粉酶是小鼠腮腺的主要分泌蛋白，它们以恒定比例出现。在此，我们描述了PSP基因的分离，并通过对该基因和唾液淀粉酶基因的表达分析表明，这两个基因在成年动物中以协同方式转录，而在出生后发育过程中的激活模式不同。我们提出了一种解释，即涉及腺泡细胞分化不同阶段基因的激活，导致成年后基因达到最大且成比例的表达。
