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新西兰黑鼠（NZB）体内特异性和非特异性抑制细胞活性

Specific and non-specific suppressor cell activity in NZB mice.

作者信息

Cooke A, Hutchings P, Nayak R

出版信息

Immunology. 1980 Jul;40(3):335-42.

PMID:6159307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458064/
Abstract

Non-specific and specific suppressor cell activity has been examined in both young and old NZB mice and compared to normal CBA mice. Both young and old NZB mice are shown to be able to generate antigen non-specific and specific suppressor cells in response to Con A and rat RBC respectively. In addition, antigen-specific suppressor cells which suppress the experimental induction of red cell autoantibodies do not influence the spontaneous development or course of autoimmune haemolytic anaemia. Subsequent experiments showed that this is probably due to differences in specificity of induced and spontaneous autoantibodies.

摘要

在年轻和年老的新西兰黑鼠（NZB）中检测了非特异性和特异性抑制细胞活性，并与正常的CBA小鼠进行了比较。结果显示，年轻和年老的NZB小鼠分别能够针对刀豆蛋白A（Con A）和大鼠红细胞产生抗原非特异性和特异性抑制细胞。此外，抑制红细胞自身抗体实验诱导的抗原特异性抑制细胞并不影响自身免疫性溶血性贫血的自然发生或病程。后续实验表明，这可能是由于诱导性和自发性自身抗体在特异性上存在差异。

相似文献

1
Specific and non-specific suppressor cell activity in NZB mice.新西兰黑鼠（NZB）体内特异性和非特异性抑制细胞活性
Immunology. 1980 Jul;40(3):335-42.
2
The role of suppressor T cells in the expression of autoimmune haemolytic anaemia in NZB mice.抑制性T细胞在NZB小鼠自身免疫性溶血性贫血表达中的作用。
Clin Exp Immunol. 1981 Sep;45(3):496-503.
3
Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice.Lyt-2阳性T细胞的扩增与新西兰黑鼠的功能损伤及自身免疫性溶血性贫血相关。
J Immunol. 1985 Oct;135(4):2432-7.
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In vitro regulation of the pathogenic autoantibody response of New Zealand black mice. I. Loss with age of suppressive activity in T cell populations.新西兰黑鼠致病性自身抗体反应的体外调节。I. T细胞群体中抑制活性随年龄的丧失。
J Immunol. 1985 Jun;134(6):3838-44.
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Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.（新西兰黑鼠×新西兰白鼠）F1代小鼠实验性诱导自身抗体调控中的性别差异。
Immunology. 1980 Dec;41(4):819-23.
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Differences between normal and autoimmune T cell responses to autologous erythrocytes and haemoglobin: impairment of haptoglobin-mediated inhibition in NZB spleen cells.正常和自身免疫性T细胞对自体红细胞和血红蛋白反应的差异：NZB脾细胞中触珠蛋白介导的抑制作用受损。
J Autoimmun. 1996 Aug;9(4):453-62. doi: 10.1006/jaut.1996.0062.
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Autoreactive T cell specificity in autoimmune hemolytic anemia of the NZB mouse.NZB小鼠自身免疫性溶血性贫血中的自身反应性T细胞特异性
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Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.诱导性红细胞自身抗体的抑制依赖于Lyt 1细胞。
Immunology. 1985 Oct;56(2):269-73.
9
Age-dependent changes of the levels of suppressor and helper T cells in New Zealand black mice.新西兰黑鼠中抑制性T细胞和辅助性T细胞水平的年龄依赖性变化
Jpn J Exp Med. 1980 Dec;50(6):415-21.
10
Generation of anti-NZB red blood cell antibody-forming plasma cells from bone marrow cultures of syngeneic and allogeneic mice: functional modulation of helper T-cell subsets in autosensitization.从同基因和异基因小鼠的骨髓培养物中产生抗NZB红细胞抗体形成浆细胞：自身致敏中辅助性T细胞亚群的功能调节。
Immunology. 1983 Mar;48(3):579-86.

引用本文的文献

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Regulatory T cells essential to prevent the loss of self-tolerance in murine models of erythrocyte-specific autoantibody responses.调节性 T 细胞对于防止红细胞特异性自身抗体反应的小鼠模型中自身耐受的丧失至关重要。
Immunol Res. 2011 Dec;51(2-3):134-44. doi: 10.1007/s12026-011-8259-1.
2
Haemolytic disease in mice induced by transplantation of hybridoma cells secreting monoclonal anti-erythrocyte autoantibodies.分泌单克隆抗红细胞自身抗体的杂交瘤细胞移植诱导的小鼠溶血性疾病
Immunology. 1982 Nov;47(3):569-72.
3
The role of suppressor T cells in the expression of autoimmune haemolytic anaemia in NZB mice.抑制性T细胞在NZB小鼠自身免疫性溶血性贫血表达中的作用。
Clin Exp Immunol. 1981 Sep;45(3):496-503.
4
Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.（新西兰黑鼠×新西兰白鼠）F1代小鼠实验性诱导自身抗体调控中的性别差异。
Immunology. 1980 Dec;41(4):819-23.
5
Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.患有X连锁B淋巴细胞缺陷的小鼠中缺乏自身抗原特异性脾抑制细胞。
Immunology. 1980 Dec;41(4):815-8.

本文引用的文献

1
Antibody elution from red blood cells.红细胞抗体洗脱
J Clin Pathol. 1963 Jan;16(1):70-3. doi: 10.1136/jcp.16.1.70.
2
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
3
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
4
Induction of red cell autoantibodies in normal mice.正常小鼠中红细胞自身抗体的诱导
Nat New Biol. 1973 Jun 13;243(128):213-4. doi: 10.1038/newbio243213a0.
5
Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice.
J Immunol. 1973 Jul;111(1):52-7.
6
Autoimmune haemolytic anaemia induced in mice immunized with rat erythrocytes.用大鼠红细胞免疫小鼠诱导产生的自身免疫性溶血性贫血。
Clin Exp Immunol. 1974 Jun;17(2):319-27.
7
Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice.NZB 小鼠和 NZB×NZW F1 杂交小鼠与其他品系小鼠免疫反应性的比较。
J Exp Med. 1969 Nov 1;130(5):1093-105. doi: 10.1084/jem.130.5.1093.
8
Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice.成年NZB及NZB-NZW F1小鼠相对缺乏诱导耐受性的能力。
J Exp Med. 1969 Jan 1;129(1):123-39. doi: 10.1084/jem.129.1.123.
9
Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction.新西兰黑-新西兰白（NZB-W）小鼠在移植物抗宿主反应中胸腺抑制细胞随年龄增长而丧失。
J Immunol. 1974 Nov;113(5):1618-25.
10
Decline in suppressor T cell function with age in female NZB mice.雌性新西兰黑小鼠随着年龄增长抑制性T细胞功能下降。
J Immunol. 1974 Jan;112(1):9-16.

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