Martin C L, Pachman L M
Arthritis Rheum. 1980 Nov;23(11):1256-61. doi: 10.1002/art.1780231105.
Synovial fluid of 20 children with seronegative juvenile rheumatoid arthritis (JRA) and 20 patients with other joint pathology was examined for levels of total hemolytic complement and selected components, immune complexes, and alpha 2-macroglobulin (alpha 2-M). When adjusted for total protein, synovial levels of total hemolytic complement, C3, C4, and alpha 2-M did not differ significantly in the two groups. The concentrations of IgM and IgG were elevated in the JRA synovial fluid, but immune complexes were not increased when compared with non-JRA group as determined by the Raji cell technique. alpha 2-M activity against substrates of C1 esterase was absent. therefore, evidence of specific increase in immune complexes and complement activation was sought but not found, suggesting that they may not be a major factor in the pathogenesis of seronegative, pauciarticular JRA.
对20例血清阴性幼年类风湿性关节炎（JRA）患儿及20例患有其他关节病变的患者的滑液进行了检测，以测定总溶血补体及选定补体成分、免疫复合物和α2-巨球蛋白（α2-M）的水平。经总蛋白校正后，两组的总溶血补体、C3、C4及α2-M的滑液水平无显著差异。JRA滑液中IgM和IgG浓度升高，但采用Raji细胞技术测定时，与非JRA组相比，免疫复合物并未增加。α2-M对C1酯酶底物无活性。因此，虽试图寻找免疫复合物特异性增加及补体激活的证据，但未找到，这表明它们可能不是血清阴性少关节型JRA发病机制中的主要因素。
