克罗恩病中的HLA抗原分布及HLA单倍型分离
HLA antigen distribution and HLA haplotype segregation in Crohn's disease.
作者信息
Peña A S, Biemond I, Kuiper G, Weterman I T, van Leeuwen A, Schreuder I, van Rood J J
出版信息
Tissue Antigens. 1980 Jul;16(1):56-61. doi: 10.1111/j.1399-0039.1980.tb00287.x.
Abstract
A study of the HLA-A, -B, -C, and -DR antigens in patients with Crohn's disease and controls did not reveal a significant strong association with a particular HLA antigens. A segregation analysis of parental HLA haplotypes in nine families with at least two children suffering from Crohn's disease did not show a significant deviation from the expected Mendelian segregation.
摘要
一项针对克罗恩病患者及对照人群的HLA - A、- B、- C和 - DR抗原的研究未发现与特定HLA抗原存在显著的强关联。对九个至少有两个孩子患克罗恩病的家庭的亲代HLA单倍型进行分离分析，结果未显示出与预期孟德尔分离存在显著偏差。
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