Rga（罗杰斯）与HLA区域：连锁与关联

Rga (Rodgers) and the HLA region: linkage and associations.

作者信息

Giles C M, Gedde-Dahl T, Robson E B, Thorsby E, Olaisen B, Arnason A, Kissmeyer-Nielsen F, Schreuder I

出版信息

Tissue Antigens. 1976 Aug;8(2):143-9.

Abstract

In 19 families with 97 children the segregation of Rga (Rodgers) was found to be compatible with Mendelian inheritance and five backcross and 14 intercross families were found among HLA and Bf typed families. Close linkage (lods + 17.82) without recombination was found between Rg and the HLA region, with a direct count of 96 nonrecombinant meioses for Rg-HLA-B. Rg- was strongly associated with HLA-B8 (29 of 30 haplotypes) and probably associated with Bw40, but did occur on other HLA-B haplotypes. By inference Rg- is negatively associated with Ch- (Chido). The Rg-Ch- haplotype has not been observed. Rga and Cha may or may not be coded for by different sites of the same cistron closely linked to HLA-B:C and cannot as yet be excluded from being parts of B or C.

摘要

在19个家庭的97名子女中，发现Rga（罗杰斯）的分离符合孟德尔遗传规律，并且在HLA和Bf分型的家庭中发现了5个回交家庭和14个杂交家庭。在Rg与HLA区域之间发现紧密连锁（lod值为+17.82）且无重组，直接计数Rg-HLA-B有96个非重组减数分裂。Rg-与HLA-B8强烈相关（30个单倍型中有29个），可能与Bw40相关，但也确实出现在其他HLA-B单倍型上。由此推断，Rg-与Ch-（奇多）呈负相关。尚未观察到Rg-Ch-单倍型。Rga和Cha可能由与HLA-B:C紧密连锁的同一顺反子的不同位点编码，也可能不是，目前尚不能排除它们是B或C的一部分。