Fadel H E, Reynolds A, Stallings M, Abraham E C
Am J Obstet Gynecol. 1981 Feb 15;139(4):397-402. doi: 10.1016/0002-9378(81)90315-x.
The levels of minor (glycosylated) hemoglobins in maternal blood during labor and in cord blood at delivery were determined in four groups of women: 20 normal, 22 probably normal, 20 Class A diabetic, and eight overt diabetic women. Maternal HbA, was not significantly increased in the diabetic patients, thereby reflecting adequate metabolic control. In the cord blood, the percentage of the minor hemoglobin HbF1c, which has been shown to be a mixture of acetylated glycosylated HbF, and the ratios HbF1c/HbF and HbA1/hbA were significantly increased in fetuses delivered of diabetic mothers. This supports the view that these fetuses are hyperglycemic in utero. However, there was no correlation between cord blood glycosylated hemoglobins and the birth weight ratio, a sensitive indicator of relative changes in the birth weight.
对四组女性进行了测定，分别为20名正常女性、22名可能正常的女性、20名A类糖尿病女性和8名显性糖尿病女性，以确定分娩时母血中次要（糖基化）血红蛋白水平以及分娩时脐血中的该水平。糖尿病患者的母体糖化血红蛋白A1未显著增加，从而反映出代谢控制良好。在脐血中，次要血红蛋白HbF1c（已证明是乙酰化糖基化HbF的混合物）的百分比以及HbF1c/HbF和HbA1/hbA的比率在糖尿病母亲所分娩胎儿中显著增加。这支持了这些胎儿在子宫内处于高血糖状态的观点。然而，脐血糖基化血红蛋白与出生体重比（出生体重相对变化的敏感指标）之间没有相关性。
