糖尿病母亲所生新生儿围产期血糖控制评估
Perinatal assessment of glycaemic control in newborn infants of diabetic mothers.
作者信息
Gouédard H A, Ménez J F, Meskar A, Caroff J, Lucas D, Legendre J M
出版信息
Diabetologia. 1984 Dec;27(6):553-7. doi: 10.1007/BF00276966.
The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significant difference in blood glucose could be found between control and infants of diabetic mothers. C-peptide levels were higher in infants of diabetic mothers compared with control infants (p less than 0.01). On day 7 after birth, the C-peptide levels remained higher only in infants of Class B, C, D diabetic mothers. Glycosylated haemoglobin was lower in the venous blood of infants than of their mothers (p less than 0.001). Glycosylated haemoglobin was lower in control mothers than in diabetic mothers (p less than 0.05), but it was higher in the venous blood samples from control infants compared with infants of diabetic mothers at delivery (p less than 0.05) and 7 days after (p less than 0.01). At delivery infants' glycaemia and infants' glycosylated haemoglobin correlated (r = 0.44, p less than 0.02). C-Peptide and glycosylated haemoglobin levels in infants at delivery also correlated (r = -0.42, p less than 0.05).
对11名对照孕妇和20名胰岛素依赖型糖尿病孕妇及其婴儿在分娩时和出生后第7天的血糖控制情况进行了研究。分娩时，糖尿病母亲的婴儿静脉血糖低于对照婴儿（p<0.02）。出生7天后，对照婴儿和糖尿病母亲的婴儿之间血糖无显著差异。糖尿病母亲的婴儿C肽水平高于对照婴儿（p<0.01）。出生后第7天，只有B、C、D类糖尿病母亲的婴儿C肽水平仍较高。婴儿静脉血中的糖化血红蛋白低于其母亲（p<0.001）。对照母亲的糖化血红蛋白低于糖尿病母亲（p<0.05），但在分娩时（p<0.05）和出生7天后（p<0.01），对照婴儿静脉血样本中的糖化血红蛋白高于糖尿病母亲的婴儿。分娩时婴儿血糖与婴儿糖化血红蛋白相关（r = 0.44，p<0.02）。分娩时婴儿的C肽与糖化血红蛋白水平也相关（r = -0.42，p<0.05）。
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