Olsson A G, Blombäck M, Ekelund L G
Artery. 1980;7(3):206-14.
In order to study the possible relation between blood viscosity and exercise ST segment depressions in hyperlipidemia the former was lowered by infusion of dextran and by treatment with clofibrate 1 g twice daily. Acute decrease of blood viscosity with dextran infusion in two cases increased the ST segment depressions during work. Nine subjects with asymptomatic hyperlipidemia, hyperfibrinogenemia and exercise ST segment depressions were treated with clofibrate in order to lower plasma fibrinogen and serum lipids. This did not influence the area of ST segment depression with either Frank leads or CH leads as determined by computer estimation. As the plasma fibrinogen level is of major importance for the blood viscosity it is concluded that the ischaemic ST segment depression seen in hyperlipidemia is not due to increased blood viscosity but more likely to a premature subclinical coronary atherosclerosis.
为研究高脂血症患者血液粘度与运动ST段压低之间的可能关系，通过输注右旋糖酐和每日两次服用1克氯贝丁酯来降低前者。2例患者输注右旋糖酐后血液粘度急性降低，工作期间ST段压低增加。9例无症状高脂血症、高纤维蛋白原血症和运动ST段压低的受试者接受氯贝丁酯治疗，以降低血浆纤维蛋白原和血脂。计算机评估结果显示，这对Frank导联或CH导联的ST段压低面积均无影响。由于血浆纤维蛋白原水平对血液粘度至关重要，因此得出结论，高脂血症中出现的缺血性ST段压低并非由于血液粘度增加，而更可能是由于过早出现的亚临床冠状动脉粥样硬化。
