Rabe L S, Buck S H, Moreno L, Burks T F, Dafny N
Brain Res Bull. 1980 Nov-Dec;5(6):755-8. doi: 10.1016/0361-9230(80)90216-6.
The effects, in rats, of peripherally administered capsaicin were evaluated on body temperature and on brain neurophysiological activity. Capsaicin (5 mg/kg, SC) produced a rapid, long-lasting fall in body temperature. A second dose given 4.5 hr after the first showed a moderate decrement in hypothermic effect. The same dose of capsaicin caused discernible changes in deep EEG activity in the anterior hypothalamus (AH), medial habenula (HB), substantia nigra (SN), and dorsal raphe (DR). The EEG changes were more pronounced at doses of 10 and 20 mg/kg. Capsaicin in all doses modified sensory evoked responses recorded from all four brain areas. Response amplitudes after acoustic stimulation were increased at all doses of capsaicin in a dose related pattern. Photic evoked responses, like body temperature effects, showed diminished effects with second and third doses. Peripherally administered capsaicin, therefore, can affect body temperature and brain electrical activity.
研究评估了外周给予辣椒素对大鼠体温及脑神经生理活动的影响。辣椒素（5毫克/千克，皮下注射）可使体温迅速且持久下降。首次给药4.5小时后给予第二剂，体温降低效应有所减弱。相同剂量的辣椒素可引起下丘脑前部（AH）、内侧缰核（HB）、黑质（SN）和中缝背核（DR）深部脑电图活动的明显变化。10毫克/千克和20毫克/千克剂量时脑电图变化更为显著。所有剂量的辣椒素均改变了从这四个脑区记录到的感觉诱发电位。在所有剂量的辣椒素作用下，声刺激后的反应幅度呈剂量相关模式增加。光诱发电位与体温效应相似，第二剂和第三剂时效应减弱。因此，外周给予辣椒素可影响体温和脑电活动。
