Szikszay M, Benedek G, Obál F
Pharmacol Biochem Behav. 1983 Mar;18(3):373-8. doi: 10.1016/0091-3057(83)90457-4.
Body temperature changes after the administration of 8 mg/kg morphine sulphate were studied in freely-moving and restrained rats, which were pretreated with capsaicin (300 mg/kg). Morphine caused a hyperthermic response irrespective of the previous capsaicin treatment in freely-moving rats; the lag time from the application of morphine to the hyperthermic maximum was, however, significantly delayed in capsaicin pretreated rats. A careful habituation to the experimental procedure (including injections, taking temperature, etc.) facilitated the hyperthermic response both in the pretreated and the control groups. Restrained rats typically showed a hypothermic response to the same dose of morphine. The drop of body temperature in habituated animals was significantly larger in the case of capsaicin pretreated rats. This potentiation of the hypothermic effect of morphine can be regarded as the primary site of interaction between capsaicin and morphine. Since capsaicin pretreated rats also showed an exaggerated thermoregulatory response to experimental stress, we conclude that the thermoregulatory effects of morphine and endogenous opiates are facilitated after capsaicin pretreatment.
在自由活动和束缚状态下的大鼠中研究了给予8mg/kg硫酸吗啡后的体温变化，这些大鼠预先用辣椒素（300mg/kg）进行了预处理。在自由活动的大鼠中，无论先前是否用辣椒素处理，吗啡都会引起体温升高反应；然而，在预先用辣椒素处理的大鼠中，从给予吗啡到体温升高最大值的延迟时间显著延长。对实验程序（包括注射、测量体温等）进行仔细的习惯化处理，可促进预处理组和对照组的体温升高反应。束缚状态下的大鼠通常对相同剂量的吗啡表现出体温降低反应。在习惯化的动物中，预先用辣椒素处理的大鼠体温下降幅度明显更大。吗啡体温降低作用的这种增强可被视为辣椒素与吗啡之间相互作用的主要部位。由于预先用辣椒素处理的大鼠对实验应激也表现出夸张的体温调节反应，我们得出结论，辣椒素预处理后，吗啡和内源性阿片类物质的体温调节作用得到促进。
