氨己烯酸与抑郁症。
Vigabatrin and depression.
作者信息
Ring H A, Crellin R, Kirker S, Reynolds E H
机构信息
Department of Neurology, Maudsley Hospital, London.
出版信息
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):925-8. doi: 10.1136/jnnp.56.8.925.
Abstract
Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.
摘要
报告了10例在使用vigabatrin治疗顽固性癫痫过程中出现重度抑郁发作的患者。抑郁通常在治疗早期出现，但如果延迟出现则与近期剂量增加有关。抑郁症状出现在每日剂量1.5克至4克之间，通常但并非总是在患者癫痫发作频率降低时出现。大多数患者有情感障碍史，有时与其他GABA能药物有关。这些观察结果支持GABA能机制在情绪障碍生物学中可能发挥的作用。
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