Arato J, Michel R P, Baxter J D
J Otolaryngol. 1980 Dec;9(6):482-6.
A unique case of adenoid cystic carcinoma arising in a ceruminous gland, with widespread pulmonary metastases, is presented. This is the first case in the English literature in which the diagnosis was made from material obtained by needle aspiration from a pulmonary metastasis. The literature is reviewed and the histological features and clinical course are discussed in the paper. Adenoid cystic carcinoma is the most common tumor of ceruminous gland origin, and is the only one which produces widespread metastases in the lungs. Tumors arising from ceruminous glands are slightly more prevalent in females, and pulmonary metastases occur almost three times as often in females as in males. Suggested treatment is wide local excision of the primary tumor and of local recurrences, and excision of distant metastases when possible. Irradiation is useful only for palliation. All patients, but especially females, should be followed carefully for the detection of possible pulmonary metastases.
本文报道了一例罕见的发生于耵聍腺的腺样囊性癌，并伴有广泛肺转移。这是英文文献中首例通过针吸获取肺转移灶组织进行诊断的病例。本文回顾了相关文献，并讨论了其组织学特征和临床病程。腺样囊性癌是最常见的源自耵聍腺的肿瘤，也是唯一能在肺部产生广泛转移的肿瘤。源自耵聍腺的肿瘤在女性中略为常见，肺转移在女性中的发生率几乎是男性的三倍。建议的治疗方法是广泛局部切除原发肿瘤及局部复发灶，尽可能切除远处转移灶。放疗仅用于缓解症状。所有患者，尤其是女性，应密切随访，以便发现可能的肺转移。
