乙肝病毒e抗原与原发性肝细胞癌
Hepatitis B virus e antigen and primary hepatocellular carcinoma.
作者信息
Lin T M, Chen C J, Lu S N, Chang A S, Chang Y C, Hsu S T, Liu J Y, Liaw Y F, Chang W Y
机构信息
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Republic of China.
出版信息
Anticancer Res. 1991 Nov-Dec;11(6):2063-5.
Serum samples from 243 cases of primary hepatocellular carcinoma (PHC) and 302 non-PHC hospital controls were tested for hepatitis B virus (HBV) surface antigen (HBsAg), antibody to HBsAg (anti-HBs), antibody to HBV core antigen (anti-HBc), HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) with radioimmunoassays using commercial kits. A total of 236 (97%) PHC cases and 302 (100%) hospital controls were positive for one or more HBV markers. While 188 (77%) PHC cases and 57 (19%) controls were positive for HBsAg, 44 (18%) PHC cases and 5 (2%) controls were positive for both BHsAg and HBeAg. Statistically significant associations with PHC were observed for HBsAg and HBeAg with an odds ratio (OR) of 10.0 and 3.2, respectively, when age, sex and other markers were adjusted. The stratification analysis of interactive effects of HBV infection markers on the development of PHC showed that HBeAg carrier status may increase PHC risk associated with HBsAg status.
采用商用试剂盒，通过放射免疫分析法对243例原发性肝细胞癌（PHC）患者和302例非PHC医院对照者的血清样本进行乙肝病毒（HBV）表面抗原（HBsAg）、抗HBsAg抗体（抗-HBs）、抗HBV核心抗原抗体（抗-HBc）、HBV e抗原（HBeAg）和抗HBeAg抗体（抗-HBe）检测。共有236例（97%）PHC患者和302例（100%）医院对照者的一种或多种HBV标志物呈阳性。188例（77%）PHC患者和57例（19%）对照者的HBsAg呈阳性，44例（18%）PHC患者和5例（2%）对照者的HBsAg和HBeAg均呈阳性。在对年龄、性别和其他标志物进行校正后，观察到HBsAg和HBeAg与PHC存在统计学显著关联，优势比（OR）分别为10.0和3.2。HBV感染标志物对PHC发生的交互作用分层分析表明，HBeAg携带状态可能会增加与HBsAg状态相关的PHC风险。
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