Baldo B A
Agents Actions. 1982 Jul;12(3):333-9. doi: 10.1007/BF01965399.
Following the injection of turpentine and carrageenan into rats, laboratory models for counter irritation were assessed by measuring changes in paw thicknesses and serum acute phase alpha 2-macroglobulin concentrations. Both indices of inflammation were also examined in groups of rats dosed with 6-mercaptopurine, the best inhibitor found so far of elevated levels of alpha 2-macroglobulin in rat serum. Results showed that there is no relationship between the degree of irritant-induced inhibition of inflammation and the serum concentration of the acute phase protein. Hence, at least in the models for counter irritation used in this study, alpha 2-macroglobulin cannot be viewed as an endogenous anti-inflammatory protein.
在向大鼠注射松节油和角叉菜胶后，通过测量爪厚度的变化和血清急性期α2-巨球蛋白浓度来评估抗刺激的实验室模型。还对给予6-巯基嘌呤的大鼠组的两种炎症指标进行了检测，6-巯基嘌呤是迄今为止发现的对大鼠血清中升高的α2-巨球蛋白水平最有效的抑制剂。结果表明，刺激诱导的炎症抑制程度与急性期蛋白的血清浓度之间没有关系。因此，至少在本研究中使用的抗刺激模型中，α2-巨球蛋白不能被视为一种内源性抗炎蛋白。
