Hirschelmann R, Schade R
Int J Tissue React. 1986;8(6):469-73.
Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-SAI arthritis, although on the whole the acute-phase reaction is relatively weak. The steroid dexamethasone and the nonsteroid benoxaprofen caused strong antiinflammatory activity at low doses. The data presented complete the picture of 6-SAI arthritis as a special inflammatory reaction in rats.
6-磺胺氨基吲唑诱导的老年大鼠关节炎，经超氧化物歧化酶、过氧化物酶或去铁胺治疗一周后并未受到抑制。由此得出结论，氧自由基在6-磺胺氨基吲唑关节炎的发病机制中几乎不发挥特殊作用。在6-磺胺氨基吲唑关节炎中，C反应蛋白和铜蓝蛋白也被证明是急性期反应物，尽管总体而言急性期反应相对较弱。类固醇地塞米松和非类固醇贝诺洛芬在低剂量时具有很强的抗炎活性。所呈现的数据完善了6-磺胺氨基吲唑关节炎作为大鼠特殊炎症反应的全貌。
