Hirschelmann R, Schade R, Bekemeier H
Martin-Luther-Universität Halle-Wittenberg, Sektion Pharmazie, Wissenschaftsbereich Pharmakologie, Halle, Saale, DDR.
Agents Actions. 1990 Jun;30(3-4):412-7. doi: 10.1007/BF01966306.
Experiments in rats suffering from primary acute adjuvant inflammation showed independent changes in serum acute phase protein concentration and macroscopic paw inflammation during antiinflammatory treatment: soybean trypsin inhibitor and horse-radish peroxidase caused antiinflammatory effects but simultaneously produced increased alpha 2 macroglobulin levels. On the other hand, cycloheximide significantly inhibited the increase of alpha 2 macroglobulin concentration in adjuvant inflammation, however, it had no antiinflammatory effect. All forms of treatment caused even some change in protein plasma levels of healthy rats which probably relates to an activation of cells producing interleukin-1, interleukin-6, and/or hepatocyte stimulating factor which trigger the synthesis of acute phase proteins in the liver. In inflamed rats, the snake venom batroxobin caused a significant decrease in the fibrinogen level whereas the paw swelling remained completely unaffected. Therefore, it seems to be doubtful whether acute phase proteins essentially contribute to the modulation of acute inflammatory reaction in primary rat adjuvant inflammation.
在患有原发性急性佐剂性炎症的大鼠身上进行的实验表明，在抗炎治疗期间，血清急性期蛋白浓度和肉眼可见的爪部炎症出现了独立变化：大豆胰蛋白酶抑制剂和辣根过氧化物酶具有抗炎作用，但同时会使α2巨球蛋白水平升高。另一方面，放线菌酮显著抑制了佐剂性炎症中α2巨球蛋白浓度的升高，然而，它没有抗炎作用。所有形式的治疗甚至都使健康大鼠的血浆蛋白水平发生了一些变化，这可能与产生白细胞介素-1、白细胞介素-6和/或肝细胞刺激因子的细胞激活有关，这些因子会触发肝脏中急性期蛋白的合成。在炎症大鼠中，蛇毒巴曲酶导致纤维蛋白原水平显著降低，而爪部肿胀则完全未受影响。因此，急性期蛋白是否在原发性大鼠佐剂性炎症中对急性炎症反应的调节起重要作用似乎值得怀疑。
