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渗透稳定剂对产气荚膜梭菌肠毒素诱导的Vero细胞形态和通透性改变的保护作用。

Protective effects of osmotic stabilizers on morphological and permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin.

作者信息

McClane B A, McDonel J L

出版信息

Biochim Biophys Acta. 1981 Mar 6;641(2):401-9. doi: 10.1016/0005-2736(81)90496-x.

DOI:10.1016/0005-2736(81)90496-x
PMID:6163461
Abstract

Culture medium made hypertonic by the addition of osmotic stabilizers such as sucrose, poly(ethylene glycol), dextran and bovine serum albumin protected against changes in morphology and plasma membrane permeability induced by Clostridium perfringes enterotoxin. The protection did not appear to be due to binding inhibition. Results of these studies support an osmotic disruption mechanism for the action of the enterotoxin. A comprehensive model of the enterotoxin's action based on an osmotic disruption mechanism is proposed.

摘要

通过添加蔗糖、聚乙二醇、右旋糖酐和牛血清白蛋白等渗透稳定剂制成的高渗培养基可防止产气荚膜梭菌肠毒素引起的形态变化和质膜通透性改变。这种保护作用似乎不是由于结合抑制。这些研究结果支持了肠毒素作用的渗透破坏机制。提出了一种基于渗透破坏机制的肠毒素作用综合模型。

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