P物质及其天然类似物对清醒大鼠胃排空的影响。
Effect of substance P and its natural analogues on gastric emptying of the conscious rat.
作者信息
Bertaccini G, de Castiglione R, Scarpignato C
出版信息
Br J Pharmacol. 1981 Feb;72(2):221-3. doi: 10.1111/j.1476-5381.1981.tb09116.x.
Abstract
1 Substance P and its natural analogues were tested for their effect on gastric emptying in the rat. 2 Substance P and kassinin were virtually inactive even at the maximum dose tests. 3 The other tachykinins significantly delayed gastric emptying their effect being quite remarkable with 100 micrograms/kg. The lowest doses (30 microgram/kg) caused a slight and non-significant increase in emptying rate. 4 The effect on gastric emptying was most probably correlated with a spasmogenic effect on the gastroduodenal junction, as pointed out in previous work.
摘要
- 对P物质及其天然类似物对大鼠胃排空的影响进行了测试。2. P物质和卡辛宁即使在最大剂量测试时实际上也无活性。3. 其他速激肽显著延迟胃排空，100微克/千克时其作用相当显著。最低剂量（30微克/千克）使排空率略有增加但不显著。4. 如先前工作中所指出的，对胃排空的影响很可能与对胃十二指肠连接处的致痉挛作用相关。
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本文引用的文献
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Action of caerulein on gastric emptying of the conscious rat.蛙皮素对清醒大鼠胃排空的作用。
Arch Int Pharmacodyn Ther. 1980 Aug;246(2):286-94.
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Bombesin delays gastric emptying in the rat.蛙皮素可延缓大鼠胃排空。
Digestion. 1981;21(2):104-6. doi: 10.1159/000198549.
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