蛙皮素对胃运动的作用。

Action of bombesin on the motility of the stomach.

Bertaccini G, Impicciatore M

Naunyn Schmiedebergs Arch Pharmacol. 1975;289(2):149-56.

Abstract

The tetradecapeptide bombesin was tested for its activity on the stomach in rats, dogs and men. On the rat stomach bombesin displayed a striking spasmogenic activity apparently independent from the autonomic nervous system. 2. In the dog the peptide was spasmogenic on the denervated Heidenhain pouch and the antrum. The inhibitory activity predominated on the innervated stomach and body fundus. 3. In man the peptide exerted a contracting effect on the antrum and the pylorus and an inhibitory effect on the stomach body and the fundus. In vitro studies performed on human stomach isolated strips showed a constant stimulant effect. 4. Apparently bombesin has a direct effect on the in situ rat stomach and on the isolated preparations, whereas it has an indirect effect on the other in situ innervated preparations.

摘要

对十四肽蛙皮素在大鼠、狗和人体上的胃部活性进行了测试。在大鼠胃部，蛙皮素表现出显著的致痉挛活性，显然与自主神经系统无关。2. 在狗身上，该肽对去神经支配的海登海因小胃和胃窦有致痉挛作用。在有神经支配的胃部和胃体部，抑制活性占主导。3. 在人体中，该肽对胃窦和幽门有收缩作用，对胃体和胃底部有抑制作用。对人体离体胃条进行的体外研究显示出持续的刺激作用。4. 显然，蛙皮素对原位大鼠胃和离体标本有直接作用，而对其他原位有神经支配的标本有间接作用。