干扰素免疫抑制：由一种抑制因子介导。
Interferon immunosuppression: mediation by a suppressor factor.
作者信息
Johnson H M, Blalock J E
出版信息
Infect Immun. 1980 Aug;29(2):301-5. doi: 10.1128/iai.29.2.301-305.1980.
Abstract
Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.
摘要
小鼠成纤维细胞干扰素对体外抗绵羊红细胞抗体反应的抑制作用是通过诱导脾细胞中的抑制细胞活性实现的。抑制细胞产生一种介导免疫抑制作用的可溶性因子。该抑制因子并不抑制病毒复制；因此，干扰素可能通过一种与其抗病毒作用不同的机制来调节B细胞反应。
相似文献
1
Interferon immunosuppression: mediation by a suppressor factor.干扰素免疫抑制：由一种抑制因子介导。
Infect Immun. 1980 Aug;29(2):301-5. doi: 10.1128/iai.29.2.301-305.1980.
2
Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell subsets.正常小鼠和自身免疫小鼠中抗体反应的干扰素免疫调节由抑制性T细胞亚群介导。
Int Arch Allergy Appl Immunol. 1981;64(3):353-8. doi: 10.1159/000232714.
3
Activation of a suppressor T-cell pathway by interferon.干扰素对抑制性T细胞途径的激活。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3808-12. doi: 10.1073/pnas.79.12.3808.
4
Mechanism of the suppressive effect of interferon on antibody synthesis in vivo.干扰素对体内抗体合成抑制作用的机制。
J Immunol. 1975 Apr;114(4):1323-8.
5
Inhibition of the primary in vitro antibody response by interferon preparations.干扰素制剂对体外初次抗体应答的抑制作用。
J Immunol. 1975 Jan;114(1 Pt 2):403-9.
6
Immune responses during pregnancy. Evidence of suppressor cells for splenic antibody response.孕期的免疫反应。脾脏抗体反应抑制细胞的证据。
J Exp Med. 1979 Oct 1;150(4):898-908. doi: 10.1084/jem.150.4.898.
7
Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。
J Immunol. 1974 Aug;113(2):438-44.
8
Dengue virus-induced thymus-derived suppressor cells in the spleen of mice.登革病毒在小鼠脾脏中诱导产生胸腺来源的抑制细胞。
Immunology. 1979 Dec;38(4):653-8.
9
Interferon: effects on the immune response and the mechanism of activation of the cellular response.干扰素：对免疫反应的影响及细胞反应激活机制
CRC Crit Rev Biochem. 1976 Nov;4(2):203-27. doi: 10.3109/10409237609105459.
10
Interferon and host defense systems.干扰素与宿主防御系统。
Adv Exp Med Biol. 1983;162:105-19. doi: 10.1007/978-1-4684-4481-0_11.
引用本文的文献
1
The role of a non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis: An example of Occam's Broom?非经典JAK-STAT信号通路在痘病毒感染和多发性硬化症的干扰素治疗中的作用：奥卡姆剃刀的一个例子？
JAKSTAT. 2013 Oct 1;2(4):e26227. doi: 10.4161/jkst.26227. Epub 2013 Sep 4.
2
Biosynthetic human interferon treatment of herpetic keratitis.生物合成人干扰素治疗疱疹性角膜炎。
Trans Am Ophthalmol Soc. 1983;81:785-824.
3
Recombinant mouse interferon-gamma regulation of antibody production.重组小鼠γ干扰素对抗体产生的调节
Infect Immun. 1983 Aug;41(2):546-8. doi: 10.1128/iai.41.2.546-548.1983.
4
Activation of a suppressor T-cell pathway by interferon.干扰素对抑制性T细胞途径的激活。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3808-12. doi: 10.1073/pnas.79.12.3808.
5
Human nonspecific suppressive lymphokines.人非特异性抑制性淋巴因子
J Clin Immunol. 1991 Jan;11(1):1-12. doi: 10.1007/BF00918789.
本文引用的文献
1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Purification of mouse interferon by affinity chromatography on anti-interferon globulin-sepharose.通过抗干扰素球蛋白-琼脂糖亲和层析法纯化小鼠干扰素。
J Immunol. 1973 Oct;111(4):1206-18.
3
Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。
J Immunol. 1974 Aug;113(2):438-44.
4
Interferon preparations as modifiers of immune responses.作为免疫反应调节剂的干扰素制剂。
Proc Soc Exp Biol Med. 1972 Dec;141(3):769-73. doi: 10.3181/00379727-141-36868.
5
Interferon inhibition of the primary in vitro antibody response to a thymus-independent antigen.干扰素对体外针对非胸腺依赖性抗原的初次抗体应答的抑制作用。
Cell Immunol. 1975 Nov;20(1):104-9. doi: 10.1016/0008-8749(75)90089-1.
6
Inhibition of the primary in vitro antibody response by interferon preparations.干扰素制剂对体外初次抗体应答的抑制作用。
J Immunol. 1975 Jan;114(1 Pt 2):403-9.
7
Decreased initiation factor activity in mouse L cells treated with interferon.用干扰素处理的小鼠L细胞中起始因子活性降低。
Nature. 1977 Oct 6;269(5628):536-8. doi: 10.1038/269536a0.
8
Relative ability of mitogens to stimulate production of interferon by lymphoid cells and to induce suppression of the in vitro immune response.丝裂原刺激淋巴细胞产生干扰素以及诱导体外免疫反应抑制的相对能力。
Proc Soc Exp Biol Med. 1977 Jan;154(1):138-41.
9
Immune-type interferon-induced transfer of viral resistance.免疫型干扰素诱导的病毒抗性转移。
J Immunol. 1979 Mar;122(3):1018-21.
10
Suppression of in vitro antibody response by ribosome-associated factor(s) from interferon-treated cells.干扰素处理细胞中的核糖体相关因子对体外抗体应答的抑制作用。
Cell Immunol. 1979 Apr;44(1):125-30. doi: 10.1016/0008-8749(79)90033-9.
Zotero 插件