登革病毒在小鼠脾脏中诱导产生胸腺来源的抑制细胞。
Dengue virus-induced thymus-derived suppressor cells in the spleen of mice.
作者信息
Tandon P, Chaturvedi U C, Mathur A
出版信息
Immunology. 1979 Dec;38(4):653-8.
Adoptive transfer of spleen cells obtained from mice given three weekly i.p. doses of dengue type 2 virus (DV) suppressed DV antigen-specific antibody secretion as detected by the Jerne plaque technique. This suppression was produced by non-glass-adherent cells but not by glass-adherent cells. Immune spleen cells depleted of macrophages by carbonyl iron treatment had higher suppressor activity. Immune spleen cell homogenate could transfer the activity equally well. The immune spleen cells were separated into T and B lymphocytes by a nylon wool column. B lymphocytes had no suppressor activity; almost all the suppressor activity was present in T lymphocytes. Thus, macrophages and B lymphocytes had no suppressor activity; it was mediated by T lymphocytes through soluble factors.
从每周腹腔注射三次登革2型病毒（DV）的小鼠中获取脾细胞进行过继转移，通过耶尔恩斑技术检测发现，这抑制了DV抗原特异性抗体的分泌。这种抑制作用由非玻璃黏附细胞产生，而非玻璃黏附细胞则不会产生。经羰基铁处理去除巨噬细胞的免疫脾细胞具有更高的抑制活性。免疫脾细胞匀浆能同样有效地传递这种活性。通过尼龙毛柱将免疫脾细胞分离为T淋巴细胞和B淋巴细胞。B淋巴细胞没有抑制活性；几乎所有的抑制活性都存在于T淋巴细胞中。因此，巨噬细胞和B淋巴细胞没有抑制活性；它是由T淋巴细胞通过可溶性因子介导的。
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