Elicitation of natural killer cells in beige mice by infection with vesicular stomatitis virus.
作者信息
McKinnon K P, Hale A H, Ruebush M J
出版信息
Infect Immun. 1981 Apr;32(1):204-10. doi: 10.1128/iai.32.1.204-210.1981.
Abstract
Vesicular stomatitis virus (VSV) infection of beige (bg/bg) mice induced levels of natural killer cytolytic activity comparable to that of uninfected normal bg/+ controls, but considerably less than natural killer activity in VSV-infected bg/+ mice. In contrast, VSV-infected bg/bg and bg/+ mice had essentially equivalent amounts of anti-VSV cytotoxic T-lymphocyte and antibody activity. VSV infection induced comparable levels of interferon in both bg/bg and bg/+ mice. Therefore, the decreased natural killer activity in bg/bg mice could not be attributed to an inability to produce interferon.
摘要
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