抗猴病毒40肿瘤抗原的单克隆抗体：利用2型腺病毒-猴病毒40杂交病毒分析抗原结合位点
Monoclonal antibodies against simian virus 40 tumor antigens: analysis of antigenic binding sites, using adenovirus type 2-simian virus 40 hybrid viruses.
作者信息
Deppert W, Gurney E G, Harrison R O
出版信息
J Virol. 1981 Jan;37(1):478-82. doi: 10.1128/JVI.37.1.478-482.1981.
Abstract
The antigenic binding sites of two monoclonal antibodies are located in the COOH-terminal region (clone 412) and probably in an internal region (clone 7) of simian virus 40 large T antigen. A third monoclonal antibody (clone 122), which has been shown to bind nonviral T antigen, does not react with HeLa cells infected with nondefective adenovirus type 2 (Ad2)-simian virus 40 hybrid viruses Ad2+ND1, Ad2+ND2, or Ad2+ND4.
摘要
两种单克隆抗体的抗原结合位点位于猴病毒40大T抗原的羧基末端区域（克隆412），可能还位于其内部区域（克隆7）。第三种单克隆抗体（克隆122）已被证明可结合非病毒T抗原，它不与感染无缺陷2型腺病毒（Ad2）-猴病毒40杂交病毒Ad2+ND1、Ad2+ND2或Ad2+ND4的HeLa细胞发生反应。
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