干扰素对小鼠细胞中鼠白血病病毒和脑心肌炎病毒复制影响的解离
Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells.
作者信息
Czarniecki C W, Sreevalsan T, Friedman R M, Panet A
出版信息
J Virol. 1981 Feb;37(2):827-31. doi: 10.1128/JVI.37.2.827-831.1981.
Abstract
Two subclones of Swiss mouse cells infected with Moloney murine leukemia virus (M-MuLV) were tested for their response to interferon (IFN). Whereas M-MuLV production in the two subclones was inhibited to the same extent, one of the subclones was significantly more sensitive to IFN when the antiviral effect was measured by replication of encephalomyocarditis (EMC) virus. The same subclone was also more sensitive to the anticellular activities of IFN. Additionally, NIH 3T3 cells infected with M-MuLV were completely resistant to IFN actions when EMC virus replication or the anticellular activities were tested. However, under the same conditions, M-MuLV production was completely inhibited by IFN. These results indicate that IFN may affect cell growth functions and EMC replication through mechanisms different from those by which MuLV production is inhibited.
摘要
对感染莫洛尼鼠白血病病毒（M-MuLV）的瑞士小鼠细胞的两个亚克隆进行了干扰素（IFN）反应测试。虽然两个亚克隆中M-MuLV的产生受到同等程度的抑制，但当通过脑心肌炎（EMC）病毒复制来测量抗病毒效果时，其中一个亚克隆对IFN的敏感性明显更高。同一个亚克隆对IFN的抗细胞活性也更敏感。此外，当测试EMC病毒复制或抗细胞活性时，感染M-MuLV的NIH 3T3细胞对IFN作用完全耐药。然而，在相同条件下，M-MuLV的产生被IFN完全抑制。这些结果表明，IFN可能通过与抑制MuLV产生不同的机制来影响细胞生长功能和EMC复制。
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