Foy H M, Allan I, Blumhagen J M, Cooney M K, Hall C, Fox J P
JAMA. 1981 May 1;245(17):1736-40.
Young adults vaccinated in late spring of 1978 with one dose of vaccine containing either 7 microgram or 20 microgram of A/USSR (H1N1) hemagglutinin, followed by a dose of trivalent (A/USSR, A/Texas, B/Hong Kong) vaccine, were observed through an epidemic of A/Brazil influenza in the winter of 1978-1979, and of influenza B in 1979-1980. Influenza infection was diagnosed by virus isolation or serological titer rises between the spring seasons of 1978, 1979, and 1980. During the A/Brazil epidemic, rates of reported influenza-like illness and serologically confirmed H1N1 influenza infections were similar for all vaccine groups and two control groups. Naturally acquired antibody, but not vaccine-induced hemagglutination-inhibiting antibodies (HAI), appeared protective. During the influenza B epidemic, a lower rate of serologically confirmed infections was observed in the 1978 vaccine cohort than in one control group.
1978年春末接种一剂含7微克或20微克A/苏联（H1N1）血凝素疫苗，随后接种一剂三价（A/苏联、A/得克萨斯、B/香港）疫苗的年轻人，在1978 - 1979年冬季A/巴西流感流行期间以及1979 - 1980年乙型流感流行期间接受了观察。通过1978年、1979年和1980年春季之间的病毒分离或血清学滴度升高来诊断流感感染。在A/巴西流感流行期间，所有疫苗组和两个对照组报告的流感样疾病发病率以及血清学确诊的H1N1流感感染率相似。自然获得的抗体而非疫苗诱导的血凝抑制抗体（HAI）似乎具有保护作用。在乙型流感流行期间，观察到1978年疫苗队列中血清学确诊感染率低于一个对照组。
