Hsu S M, Hsu P L, Nayak R N
Hum Pathol. 1981 Mar;12(3):251-7. doi: 10.1016/s0046-8177(81)80126-8.
The lymphoid stroma of Warthin's tumor was studied using an immunoperoxidase method. We found that IgA plasma cells constituted approximately 80 per cent of the total number of plasma cells in this tumor. IgA was present also in the tumor epithelium and in the intraluminal sections. The predominance of IgA plasma cells in Warthin's tumor is in contrast to the lymphoid pattern observed in autoimmune diseases and usual host-tumor reactions. It seems likely that the lymphoid stroma of Warthin's tumor represents an exaggerated secretory immune response. The neoplastic tissue of Warthin's tumor may elaborate or contain an unknown factor that causes the accumulation of lymphoid tissue and the differentiation of IgA plasma cells.
运用免疫过氧化物酶法对沃辛瘤的淋巴样间质进行了研究。我们发现，IgA浆细胞约占该肿瘤中浆细胞总数的80%。IgA也存在于肿瘤上皮及腔内切片中。沃辛瘤中IgA浆细胞占优势，这与自身免疫性疾病及常见的宿主 - 肿瘤反应中观察到的淋巴样模式形成对比。沃辛瘤的淋巴样间质似乎代表了一种过度的分泌性免疫反应。沃辛瘤的肿瘤组织可能会产生或含有一种未知因子，该因子导致淋巴组织的积聚及IgA浆细胞的分化。
