Sunardhi-Widyaputra S, Van Damme B
Department of Pathology, II Sint Raphael University Hospital, Faculty of Medicine Catholic University of Leuven, Belgium.
Oral Surg Oral Med Oral Pathol. 1993 Sep;76(3):325-9. doi: 10.1016/0030-4220(93)90261-2.
The presence of tenascin was studied immunohistochemically in Warthin's tumor and in oncocytoma. In Warthin's tumor this extracellular matrix protein was seen in the proximity of the basement membrane zone beneath the oncocytic epithelium, in the proximity of the basement membrane of venules and of high endothelial venules, and in the reticular tissue of the lymphoid stroma. Type IV collagen was seen in the same areas as tenascin. Fibronectin was also seen in areas similar to those of tenascin and in the adjacent stroma. Tenascin was found in oncocytoma as a focal staining, and fibronectin was seen around the basement membrane and adjacent stroma. Type IV collagen was seen as a distinct staining along the basement membranes. Although the oncocytic epithelial cells in Warthin's tumor and in oncocytoma are thought to be actively proliferating cells, these two tumors differ in tenascin expression.
采用免疫组织化学方法研究了沃辛瘤和嗜酸细胞瘤中腱生蛋白的表达情况。在沃辛瘤中，这种细胞外基质蛋白可见于嗜酸细胞上皮下方的基底膜区域附近、小静脉和高内皮小静脉的基底膜附近以及淋巴样间质的网状组织中。IV型胶原在与腱生蛋白相同的区域可见。纤连蛋白也见于与腱生蛋白相似的区域及相邻的间质中。在嗜酸细胞瘤中，腱生蛋白呈局灶性染色，纤连蛋白可见于基底膜及相邻间质周围。IV型胶原沿基底膜呈明显染色。尽管沃辛瘤和嗜酸细胞瘤中的嗜酸细胞上皮细胞被认为是活跃增殖的细胞，但这两种肿瘤在腱生蛋白表达方面存在差异。
