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局部应用辣椒素对轴突反射性血管舒张的抑制作用。

Inhibition of axon reflex vasodilatation by topically applied capsaicin.

作者信息

Bernstein J E, Swift R M, Soltani K, Lorincz A L

出版信息

J Invest Dermatol. 1981 May;76(5):394-5. doi: 10.1111/1523-1747.ep12520912.

DOI:10.1111/1523-1747.ep12520912
PMID:6164737
Abstract

Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature. Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.

摘要

将辣椒素局部应用于人体皮肤会产生最初的灼痛性红斑反应，该反应在24小时内逐渐减轻，之后皮肤对组胺诱导的轴突反射性血管舒张无反应，同时对疼痛、触觉和温度的敏感性未改变。局部感觉神经末梢中P物质的耗竭被认为是这种辣椒素效应的一种可能解释。

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Inhibition of axon reflex vasodilatation by topically applied capsaicin.局部应用辣椒素对轴突反射性血管舒张的抑制作用。
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引用本文的文献

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Intradermal actions of hypertonic saline involve neural and vascular mechanisms.高渗盐水的皮内作用涉及神经和血管机制。
Br J Clin Pharmacol. 1995 Jul;40(1):98-100. doi: 10.1111/j.1365-2125.1995.tb04544.x.
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Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun;326(3):254-61. doi: 10.1007/BF00505327.
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Ir J Med Sci. 1984 Feb;153(2):47-59. doi: 10.1007/BF02937152.
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J Physiol. 1983 Feb;335:449-65. doi: 10.1113/jphysiol.1983.sp014543.
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Agents Actions. 1983 Apr;13(2-3):105-16. doi: 10.1007/BF01967311.
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