局部应用辣椒素对轴突反射性血管舒张的抑制作用。
Inhibition of axon reflex vasodilatation by topically applied capsaicin.
作者信息
Bernstein J E, Swift R M, Soltani K, Lorincz A L
出版信息
J Invest Dermatol. 1981 May;76(5):394-5. doi: 10.1111/1523-1747.ep12520912.
PMID:6164737
Abstract
Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature. Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.
摘要
将辣椒素局部应用于人体皮肤会产生最初的灼痛性红斑反应，该反应在24小时内逐渐减轻，之后皮肤对组胺诱导的轴突反射性血管舒张无反应，同时对疼痛、触觉和温度的敏感性未改变。局部感觉神经末梢中P物质的耗竭被认为是这种辣椒素效应的一种可能解释。
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