Flannigan S A, Tucker S B
Br J Ind Med. 1985 Nov;42(11):773-6. doi: 10.1136/oem.42.11.773.
Synthetic pyrethroids are neurotoxic insecticides with a low mammalian toxicity. Prior investigations have found these agents to be neither cutaneous irritants nor sensitisers. Clinically demonstrable inflammation, as judged by erythema, oedema, or vesiculation, has not been apparent. Nevertheless, paraesthesia does result from cutaneous exposure. In this investigation technical grade flucythrinate was applied to the forearms of human participants twice daily for five consecutive days. Laser Doppler velocimeter measurements were made before each topical application, with histamine phosphate being intradermally injected on termination of the study. Results of both laser Doppler velocimetry and histamine induced axon reflex vasodilatation were not statistically significant at an alpha = 0.05 level. This investigation suggests that the synthetic pyrethroids have little influence on neurogenic vasodilatation on topical exposure.
合成拟除虫菊酯是一类具有低哺乳动物毒性的神经毒性杀虫剂。先前的研究发现这些药剂既不是皮肤刺激剂也不是致敏剂。根据红斑、水肿或水疱形成判断，临床上可证实的炎症并不明显。然而，皮肤接触确实会导致感觉异常。在这项研究中，将工业级氟氰菊酯连续五天每天两次涂抹于人类受试者的前臂。在每次局部涂抹前使用激光多普勒血流仪进行测量，并在研究结束时皮内注射磷酸组胺。在α = 0.05水平时，激光多普勒血流仪测量结果和组胺诱导的轴突反射性血管舒张结果均无统计学意义。这项研究表明，合成拟除虫菊酯局部接触时对神经源性血管舒张影响很小。
