辣椒素局部治疗后人体皮肤对轻度损伤的血管和感觉反应。
Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.
作者信息
Carpenter S E, Lynn B
出版信息
Br J Pharmacol. 1981 Jul;73(3):755-8. doi: 10.1111/j.1476-5381.1981.tb16812.x.
Abstract
1 Immediately after several topical applications of capsaicin at 2-hourly intervals, human forearm skin would no longer develop flare (vasodilation) around a small injury. At the same time heat pain thresholds were reduced on average by 3.5 degrees C. These results are consistent with block by capsaicin of the effector side of the axon reflex, perhaps by depleting nerve terminals of substance P. 2 Over a period from several days to several weeks after treatment, flare was diminished and heat pain thresholds were slightly elevated. These changes may be due to long-lasting damage of cutaneous nerve terminals by capsaicin.
摘要
- 每隔2小时对人体前臂皮肤进行几次辣椒素局部涂抹后，皮肤在小伤口周围不再出现潮红（血管扩张）。同时，热痛阈值平均降低了3.5摄氏度。这些结果与辣椒素阻断轴突反射效应器一侧相符，可能是通过耗尽神经末梢中的P物质实现的。2. 在治疗后的几天到几周内，潮红减轻，热痛阈值略有升高。这些变化可能是由于辣椒素对皮肤神经末梢造成了持久损伤。
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