Piantino P, Pecchio F, Gallo V, Giudice L, Bonardi O
Minerva Med. 1981 May 7;72(18):1125-9.
Seric alfa-FP has been studied in acute and chronic hepatitis and in hepatocellular carcinoma. Sixty five normal subjects, 62 cirrhoses, 10 active chronic hepatitis, 12 chronic persistent hepatitis, 4 primary biliary cirrhoses and 9 hepatomas have been examined for seric alfa-FP. Abnormal seric alfa-FP (> 10 ng/ml) values agree with literature data. It is likely that hepatocellular regeneration due to viral or inflammatory disorders, can produce formation of alfa-FP and other abnormal proteins fro a depression mechanism of sue regulator gene.
已对急性和慢性肝炎以及肝细胞癌患者的血清甲胎蛋白进行了研究。对65名正常受试者、62名肝硬化患者、10名活动性慢性肝炎患者、12名慢性持续性肝炎患者、4名原发性胆汁性肝硬化患者和9名肝癌患者进行了血清甲胎蛋白检测。血清甲胎蛋白异常值(>10 ng/ml)与文献数据相符。由于病毒或炎症性疾病导致的肝细胞再生,很可能通过某种调节基因的抑制机制产生甲胎蛋白和其他异常蛋白质。