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斑秃和全秃患者的血液淋巴细胞亚群及抗体依赖性细胞介导的细胞毒性(ADCC)

Blood lymphocyte subpopulations and antibody dependent, cell-mediated cytotoxicity (ADCC) in alopecia areata and universalis.

作者信息

Gu S Q, Ros A M, Thyresson N, Wasserman J

出版信息

Acta Derm Venereol. 1981;61(2):125-9.

PMID:6165187
Abstract

T-lymphocyte subpopulations and antibody-dependent, cell-mediated cytotoxicity (ADCC) were studied in patients with alopecia areata and universalis. The proportions of T-cells with the receptors for IgG (Tg) and T-cells with receptor for IgM (Tm) were determined in 16 cases. The ADCC of unfractionated lymphocytes was examined in 5 cases. A higher proportion of Tg-cells (T-cell with low affinity for sheep red cells) and a more pronounced ADCC of the peripheral lymphocytes were found in patients with alopecia areata and universalis than in age- and sex-matched normal donors.

摘要

对斑秃和全秃患者的T淋巴细胞亚群及抗体依赖性细胞介导的细胞毒性(ADCC)进行了研究。测定了16例患者中具有IgG受体的T细胞(Tg)和具有IgM受体的T细胞(Tm)的比例。检测了5例患者未分离淋巴细胞的ADCC。与年龄和性别匹配的正常供者相比,斑秃和全秃患者中Tg细胞(对绵羊红细胞亲和力低的T细胞)比例更高,外周淋巴细胞的ADCC更明显。

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