T细胞亚群及其体外功能。斑秃和全秃患者的一项研究。

T cell subpopulations and their functions in vitro. A study in patients with alopecia areata and alopecia universalis.

作者信息

Gu S Q, Ros A M, von Stedingk L V, Thyresson N, Wasserman J

出版信息

Int Arch Allergy Appl Immunol. 1981;66(2):208-17. doi: 10.1159/000232820.

Abstract

T lymphocyte subpopulations and their in vitro activities were determined in patients with alopecia areata (AA) and alopecia universalis (AU). The frequencies of T cells with receptors for IgG and T cells with receptors for IgM were determined in 16 cases. The IgG and IgM production of B lymphocytes cocultured with autologous and allogeneic T lymphocytes in the presence of PWM was determined in 12 and 9 cases, respectively, and the antibody-dependent cell-mediated cytotoxicity (ADCC) of unfractionated lymphocytes was examined in 6 cases. Patients with AA and AU had a higher proportion of Tg cells and more pronounced ADCC of unfractionated peripheral lymphocytes than normal persons. Furthermore, PWM-induced Ig production of B lymphocytes in the presence of autologous T lymphocytes seemed to be lower than that of controls.

摘要

对斑秃（AA）和全秃（AU）患者的T淋巴细胞亚群及其体外活性进行了测定。测定了16例患者中具有IgG受体的T细胞和具有IgM受体的T细胞的频率。分别在12例和9例患者中测定了在PWM存在下与自体和异体T淋巴细胞共培养的B淋巴细胞的IgG和IgM产生，并在6例患者中检测了未分离淋巴细胞的抗体依赖性细胞介导的细胞毒性（ADCC）。与正常人相比，AA和AU患者的Tg细胞比例更高，未分离的外周淋巴细胞的ADCC更明显。此外，在自体T淋巴细胞存在下，PWM诱导的B淋巴细胞Ig产生似乎低于对照组。