Duffy F H, Bartels P H, Burchfiel J L
Electroencephalogr Clin Neurophysiol. 1981 May;51(5):455-62. doi: 10.1016/0013-4694(81)90221-2.
We illustrate the application of significance probability mapping (SPM) to the analysis of topographic maps of spectral analyzed EEG and visual evoked potential (VEP) activity from patients with brain tumors, boys with dyslexia, and control subjects. When the VEP topographic plots of tumor patients were displayed as number of standard deviations from a reference mean, more subjects were correctly identified than by inspection of the underlying raw data. When topographic plots of EEG alpha activity obtained while listening to speech or music were compared by t statistic to plots of resting alpha activity, regions of cortex presumably activated by speech or music were delineated. DIfferent regions were defined in dyslexic boys and controls. We propose that SPM will prove valuable in the regional localization of normal and abnormal functions in other clinical situations.
我们展示了显著性概率映射（SPM）在分析脑肿瘤患者、诵读困难男孩及对照受试者的经频谱分析的脑电图地形图和视觉诱发电位（VEP）活动中的应用。当将肿瘤患者的VEP地形图显示为相对于参考均值的标准差数量时，与检查基础原始数据相比，能正确识别出更多的受试者。当通过t统计量将聆听语音或音乐时获得的脑电图α活动地形图与静息α活动地形图进行比较时，推测由语音或音乐激活的皮质区域被描绘出来。诵读困难男孩和对照受试者中定义出了不同的区域。我们提出，SPM在其他临床情况下正常和异常功能的区域定位中将被证明是有价值的。
