Ong T, de Serres F J
Environ Mutagen. 1981;3(2):151-8. doi: 10.1002/em.2860030206.
Our previous studies have shown that the nitrofurans AF-2, SQ18506, and FANFT are potent mutagens in Neurospora crassa. The genetic damage produced by these chemicals at the ad-3 region in N crassa has been characterized by a series of genetic tests. The results of these tests indicate that all three agents induce a high frequency of point mutations and probably a low frequency of multilocus deletions. A comparison of the complementation patterns among the AF-2--induced ad-3B mutants and those induced by other chemical agents indicates that the spectra of intragenic alterations induced by AF-2 in N crassa are similar to those induced by monofunctional alkylating agents.
我们之前的研究表明，硝基呋喃类化合物AF-2、SQ18506和FANFT在粗糙脉孢菌中是强效诱变剂。这些化学物质在粗糙脉孢菌的ad-3区域产生的遗传损伤已通过一系列遗传学测试进行了表征。这些测试结果表明，这三种试剂均诱导高频点突变，可能还诱导低频多位点缺失。对AF-2诱导的ad-3B突变体与其他化学试剂诱导的突变体之间的互补模式进行比较表明，AF-2在粗糙脉孢菌中诱导的基因内改变谱与单功能烷基化剂诱导的谱相似。
