细胞介导免疫的调节机制。VII. 次优剂量抗原加I-J特异性同种异体效应诱导的抑制性T细胞。
Mechanisms of regulation of cell-mediated immunity. VII. Suppressor T cells induced by suboptimal doses of antigen plus an I-J-specific allogeneic effect.
作者信息
Bromberg J S, Benacerraf B, Greene M I
出版信息
J Exp Med. 1981 Feb 1;153(2):437-49. doi: 10.1084/jem.153.2.437.
Abstract
Intravenous injection of 0.01 mM 2,4,6-trinitrobenzene sulfonic acid-derivatized syngeneic lymphoid cells generates a Thy-1-positive, antigen-specific suppressor cell for contact sensitivity which requires an I-J allogeneic effect to become fully activated. It is necessary and sufficient for all allogeneic effect to be directed solely against the suppressor cell, and once activated, the cell can suppress in an H-2-unrestricted fashion. The results are discussed in the framework of entry into the suppressor pathway, the allogeneic effect as a reflection of normal physiologic processes, and the importance of I-J as a receptor and signal among cells in the suppressor pathway.
摘要
静脉注射0.01 mM 2,4,6-三硝基苯磺酸衍生的同基因淋巴细胞可产生一种Thy-1阳性、抗原特异性的接触敏感性抑制细胞，该细胞需要I-J同种异体效应才能完全激活。所有同种异体效应仅针对抑制细胞是必要且充分的，一旦激活，该细胞可以以H-2非限制性方式发挥抑制作用。本文在进入抑制途径、作为正常生理过程反映的同种异体效应以及I-J作为抑制途径中细胞间受体和信号的重要性等框架下讨论了这些结果。
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