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1
An antigen-specific signal is required for the activation of second-order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid.在对2,4,6-三硝基苯磺酸迟发型超敏反应的调节中，二阶抑制性T细胞的激活需要抗原特异性信号。
J Exp Med. 1983 Sep 1;158(3):932-45. doi: 10.1084/jem.158.3.932.
2
Suppressor T cell circuits in contact sensitivity. II. Induction and characterization of an efferent-acting, antigen-specific, H-2-restricted, monoclonal T cell hybrid-derived suppressor factor specific for DNFB contact hypersensitivity.接触敏感性中的抑制性T细胞回路。II. 针对二硝基氟苯接触性超敏反应的传出作用、抗原特异性、H-2限制性、单克隆T细胞杂交瘤衍生的抑制因子的诱导与特性分析
J Immunol. 1984 Dec;133(6):3112-20.
3
Receptor specificity of Ia-restricted T lymphoblasts activated against trinitrobenzene sulfonate-coupled spleen cells: recognition of distinct trinitrophenyl and Ia moieties.针对三硝基苯磺酸偶联脾细胞激活的Ia限制型T淋巴母细胞的受体特异性：对不同三硝基苯基和Ia部分的识别。
Cell Immunol. 1984 Mar;84(1):121-37. doi: 10.1016/0008-8749(84)90083-2.
4
Suppressor T cell circuits in contact sensitivity. III. A monoclonal T cell hybrid-derived suppressor factor specifically suppresses local DTH transfer by a DNP-specific T cell clone.接触敏感性中的抑制性T细胞回路。III. 一种单克隆T细胞杂交瘤衍生的抑制因子特异性抑制DNP特异性T细胞克隆介导的局部迟发型超敏反应转移。
J Immunol. 1986 Mar 1;136(5):1571-8.
5
Hapten-specific responses to the phenyltrimethylamino hapten. II. Regulation of delayed-type hypersensitivity by genetically restricted, anti-idiotype suppressor T cells induced by the monovalent antigen L-tyrosine-p-azophenyltrimethylammonium.对半抗原苯三甲基氨基的半抗原特异性反应。II. 由单价抗原L-酪氨酸-对-偶氮苯三甲基铵诱导的基因受限的抗独特型抑制性T细胞对迟发型超敏反应的调节。
Eur J Immunol. 1982 Apr;12(4):278-84. doi: 10.1002/eji.1830120405.
6
Mechanism of action of a T suppressor factor (TsF) in contact sensitivity: the T cell target for TsF activity in adoptive transfer of immunity is not effector cell.T抑制因子（TsF）在接触敏感性中的作用机制：在免疫的过继转移中，TsF活性的T细胞靶标不是效应细胞。
J Immunol. 1986 Sep 15;137(6):1829-35.
7
The role of I-J in the suppressor T-cell circuit which influences the effector stage of contact sensitivity: antigen together with syngeneic I-J region determinants induces and activates T suppressor cells.I-J在影响接触敏感性效应阶段的抑制性T细胞回路中的作用：抗原与同基因I-J区域决定簇一起诱导并激活T抑制细胞。
Immunology. 1983 May;49(1):191-9.
8
Hapten-specific responses to the phenyltrimethylamino hapten. V. A single chain antigen-binding I-J+ first-order T suppressor factor requires antigen to induce anti-idiotypic second-order suppressor T cells.对半抗原苯三甲基氨基的半抗原特异性反应。V. 单链抗原结合性I-J⁺一级T抑制因子需要抗原诱导抗独特型二级抑制性T细胞。
J Immunol. 1985 Feb;134(2):1010-8.
9
Auto-delayed-type hypersensitivity induced in immunodeficient mice with syngeneic modified self-antigens. II. Suppressor T cells control the autoimmune response.用同基因修饰的自身抗原在免疫缺陷小鼠中诱导的自身延迟型超敏反应。II. 抑制性T细胞控制自身免疫反应。
Scand J Immunol. 1984 Feb;19(2):111-21. doi: 10.1111/j.1365-3083.1984.tb00906.x.
10
Suppressor T cell recognition of major and minor histocompatibility alloantigens: selected suppression of MHC-directed responses by minor alloantigen Ts.抑制性T细胞对主要和次要组织相容性同种异体抗原的识别：次要同种异体抗原Ts对MHC导向反应的选择性抑制
J Immunol. 1984 Jul;133(1):16-23.

引用本文的文献

1
In vivo activity of interleukin-2: conversion of a stimulus causing unresponsiveness to a stimulus causing contact hypersensitivity by the injection of interleukin-2.白细胞介素-2的体内活性：通过注射白细胞介素-2将引起无反应性的刺激转化为引起接触性超敏反应的刺激。
Immunology. 1985 Dec;56(4):653-8.
2
Tubular antigen-derivatized cells induce a disease-protective, antigen-specific, and idiotype-specific suppressor T cell network restricted by I-J and Igh-V in mice with experimental interstitial nephritis.在患有实验性间质性肾炎的小鼠中，肾小管抗原衍生细胞诱导出一种受I-J和Igh-V限制的、具有疾病保护作用、抗原特异性和独特型特异性的抑制性T细胞网络。
J Exp Med. 1985 Jul 1;162(1):215-30. doi: 10.1084/jem.162.1.215.
3
Characterization of a third-order suppressor T cell (Ts3) induced by cryptococcal antigen(s).由隐球菌抗原诱导产生的三阶抑制性T细胞（Ts3）的特性
Infect Immun. 1987 Jul;55(7):1657-62. doi: 10.1128/iai.55.7.1657-1662.1987.
4
The control of the contact sensitivity skin reaction: T-suppressor afferent cell blocks the production of antigen-specific T-helper factor.接触敏感性皮肤反应的控制：T抑制性传入细胞阻断抗原特异性T辅助因子的产生。
Immunology. 1985 Mar;54(3):521-6.

本文引用的文献

1
Interactions between molecules (subfactors) released by different T cell sets that yield a complete factor with biological (suppressive) activity.不同T细胞集释放的分子（亚因子）之间的相互作用产生具有生物学（抑制）活性的完整因子。
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2375-8. doi: 10.1073/pnas.79.7.2375.
2
A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.抗原特异性免疫抑制中T淋巴细胞相互作用的单一主要途径。
Scand J Immunol. 1981;13(1):1-10. doi: 10.1111/j.1365-3083.1981.tb00104.x.
3
Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target.抗原和受体驱动的调节机制。VIII. 抗独特型二级T抑制细胞与交叉反应性独特型阳性、对氨基苯砷酸致敏的T细胞靶标的相互作用导致对独特型阴性、对氨基苯砷酸特异性T细胞的抑制。
J Exp Med. 1981 Jun 1;153(6):1415-25. doi: 10.1084/jem.153.6.1415.
4
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.
5
Suppressor T cell circuits.
Ann N Y Acad Sci. 1982;392:300-8. doi: 10.1111/j.1749-6632.1982.tb36115.x.
6
The role of the T acceptor cell in suppressor systems. Antigen-specific T suppressor factor acts via a T acceptor cell; this releases a nonspecific inhibitor of the transfer of contact sensitivity when exposed to antigen in the context of I-J.T 受体细胞在抑制系统中的作用。抗原特异性 T 抑制因子通过 T 受体细胞发挥作用；当在 I-J 背景下暴露于抗原时，该细胞释放接触敏感性传递的非特异性抑制剂。
Ann N Y Acad Sci. 1982;392:71-89. doi: 10.1111/j.1749-6632.1982.tb36099.x.
7
Antigen-specific suppressor T cell interactions. I. Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.抗原特异性抑制性T细胞相互作用。I. 对L-谷氨酸50-L-酪氨酸50特异的MHC限制性抑制因子的诱导。
J Immunol. 1982 Jun;128(6):2447-52.
8
Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.抗原和受体驱动的调节机制。VII. 来自传出抑制性T细胞的H-2限制性抗独特型抑制因子。
J Exp Med. 1981 Feb 1;153(2):450-63. doi: 10.1084/jem.153.2.450.
9
Antigen- and receptor-driven regulatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH genes is caused by the lack of idiotype-matched targets.抗原和受体驱动的调节机制。五、在缺乏适当VH基因的动物中，独特型偶联的脾细胞未能诱导无反应性是由于缺乏独特型匹配的靶细胞。
J Exp Med. 1980 Nov 1;152(5):1226-35. doi: 10.1084/jem.152.5.1226.
10
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。V. 独特型在抑制途径中的作用。
J Exp Med. 1980 Jul 1;152(1):161-9. doi: 10.1084/jem.152.1.161.

在对2,4,6-三硝基苯磺酸迟发型超敏反应的调节中，二阶抑制性T细胞的激活需要抗原特异性信号。

An antigen-specific signal is required for the activation of second-order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid.

作者信息

Tsurufuji M, Benacerraf B, Sy M S

出版信息

J Exp Med. 1983 Sep 1;158(3):932-45. doi: 10.1084/jem.158.3.932.

DOI:10.1084/jem.158.3.932
PMID:6193239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187103/
Abstract

Suppressor T cells (Ts-1) induced with trinitrophenyl (TNP)-conjugated syngeneic spleen cells (TNP-SC) can be enriched on antigen-coated plates and are afferent suppressors. In addition, these suppressor cells produced soluble suppressor factors (TsF) that were active in vivo. Therefore, the Ts-1 cells in the TNP system are very similar to the Ts-1 cells in other systems we have studied earlier. Further characterization of these TsF-1 revealed that TsF-1 obtained from TNP-SC-induced Ts-1 is major histocompatibility complex restricted in its activity. Injection of TNP-specific TsF-1 into naive mice did not induce Ts-2 unless additional corresponding antigen was provided. Moreover, the Ts-2 cells induced by administration of both TsF-1 and trinitrobenzene sulfonic acid were antigen specific rather than antiidiotypic.

摘要

用三硝基苯基（TNP）偶联的同基因脾细胞（TNP-SC）诱导产生的抑制性T细胞（Ts-1）可在抗原包被的平板上富集，且为传入性抑制细胞。此外，这些抑制细胞产生的可溶性抑制因子（TsF）在体内具有活性。因此，TNP系统中的Ts-1细胞与我们之前研究的其他系统中的Ts-1细胞非常相似。对这些TsF-1的进一步表征显示，从TNP-SC诱导的Ts-1获得的TsF-1其活性受主要组织相容性复合体限制。将TNP特异性TsF-1注射到未接触过抗原的小鼠体内，除非提供额外的相应抗原，否则不会诱导产生Ts-2。此外，通过同时给予TsF-1和三硝基苯磺酸诱导产生的Ts-2细胞是抗原特异性的，而非抗独特型的。