在对2,4,6-三硝基苯磺酸迟发型超敏反应的调节中，二阶抑制性T细胞的激活需要抗原特异性信号。
An antigen-specific signal is required for the activation of second-order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid.
作者信息
Tsurufuji M, Benacerraf B, Sy M S
出版信息
J Exp Med. 1983 Sep 1;158(3):932-45. doi: 10.1084/jem.158.3.932.
Abstract
Suppressor T cells (Ts-1) induced with trinitrophenyl (TNP)-conjugated syngeneic spleen cells (TNP-SC) can be enriched on antigen-coated plates and are afferent suppressors. In addition, these suppressor cells produced soluble suppressor factors (TsF) that were active in vivo. Therefore, the Ts-1 cells in the TNP system are very similar to the Ts-1 cells in other systems we have studied earlier. Further characterization of these TsF-1 revealed that TsF-1 obtained from TNP-SC-induced Ts-1 is major histocompatibility complex restricted in its activity. Injection of TNP-specific TsF-1 into naive mice did not induce Ts-2 unless additional corresponding antigen was provided. Moreover, the Ts-2 cells induced by administration of both TsF-1 and trinitrobenzene sulfonic acid were antigen specific rather than antiidiotypic.
摘要
用三硝基苯基（TNP）偶联的同基因脾细胞（TNP-SC）诱导产生的抑制性T细胞（Ts-1）可在抗原包被的平板上富集，且为传入性抑制细胞。此外，这些抑制细胞产生的可溶性抑制因子（TsF）在体内具有活性。因此，TNP系统中的Ts-1细胞与我们之前研究的其他系统中的Ts-1细胞非常相似。对这些TsF-1的进一步表征显示，从TNP-SC诱导的Ts-1获得的TsF-1其活性受主要组织相容性复合体限制。将TNP特异性TsF-1注射到未接触过抗原的小鼠体内，除非提供额外的相应抗原，否则不会诱导产生Ts-2。此外，通过同时给予TsF-1和三硝基苯磺酸诱导产生的Ts-2细胞是抗原特异性的，而非抗独特型的。
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