硫代甘油对大肠杆菌的抑制作用。
Inhibition of Escherichia coli by thioglycerol.
作者信息
Jensen K K, Javor G T
出版信息
Antimicrob Agents Chemother. 1981 Apr;19(4):556-61. doi: 10.1128/AAC.19.4.556.
Abstract
Thioglycerol inhibits the growth of various Escherichia coli strains and other microorganisms, both gram positive and gram negative. The susceptibility of organisms varies. The bactericidal action of this substance is not continuous and stops after an initial burst. At subbactericidal concentrations synthesis of ribonucleic acid is the most strongly affected. This is not due to interference with nucleoside biosynthesis or to direct inhibition of ribonucleic acid polymerase by thioglycerol.
摘要
硫代甘油可抑制多种大肠杆菌菌株以及其他革兰氏阳性和革兰氏阴性微生物的生长。不同微生物的敏感性有所差异。该物质的杀菌作用并非持续不断，而是在最初的爆发后就会停止。在低于杀菌浓度时，核糖核酸的合成受到的影响最为强烈。这并非是由于硫代甘油干扰核苷生物合成或直接抑制核糖核酸聚合酶所致。
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