硫代甘油对大肠杆菌腺苷甲硫氨酸含量的抑制作用。
Depression of adenosylmethionine content of Escherichia coli by thioglycerol.
作者信息
Javor G T
出版信息
Antimicrob Agents Chemother. 1983 Dec;24(6):860-7. doi: 10.1128/AAC.24.6.860.
Abstract
The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglycerol elevated the intracellular concentration of methionine, but the level of S-adenosylmethionine was depressed. Thioglycerol was methylated in vivo to 3-methylthio-1,2-propanediol.
摘要
对硫代甘油抑制大肠杆菌生长的机制进行了探究。生长抑制的程度取决于硫代甘油与初始细胞浓度的比例。外源添加的甲硫氨酸和几种甲硫氨酸类似物可逆转2至40 mM硫代甘油的抑制作用。暴露于硫代甘油会提高细胞内甲硫氨酸的浓度，但S-腺苷甲硫氨酸的水平会降低。硫代甘油在体内甲基化形成3-甲硫基-1,2-丙二醇。
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