Karim M A, Clelland I A, Chapman I V, Walker C H
J Perinat Med. 1981;9(3):141-4. doi: 10.1515/jpme.1981.9.3.141.
It has been suggested that changes take place in human platelets when they are exposed to fluorescent light of 10.8W/m2/sec at 460 nm. Loss of ability to aggregate and increase in turnover rate have been reported. However, studies of the effect of fluorescent light on adult platelets when exposed to the level of irradiance used clinically (3.5W/m2/sec) for 60 min did not reveal this effect. A study was therefore designed to compare the effects of bilirubin and phototherapy alone and in combination on cord and adult blood platelets obtained from jaundiced neonates. Using beta-thromboglobulin as the indicator of platelet damage, no significant change was found in platelet poor plasma from cord or adult blood following exposure to bilirubin and/or light, nor was any change found in the plasma of jaundiced neonates before and after therapy. Although the duration of exposure to light in this study was short, the results suggest that the lower levels of irradiance used clinically are not harmful to platelets and that the results of studies done with three times as much irradiance have little clinical relevance.
有人提出，当人类血小板暴露于波长为460nm、辐照度为10.8W/m²/秒的荧光下时，会发生变化。据报道，血小板的聚集能力丧失且周转率增加。然而，关于荧光对成年血小板的影响的研究表明，当暴露于临床使用的辐照度水平（3.5W/m²/秒）60分钟时，并未发现这种影响。因此，设计了一项研究来比较胆红素和光疗单独及联合使用对从黄疸新生儿获得的脐带血和成人血血小板的影响。使用β-血小板球蛋白作为血小板损伤的指标，发现脐带血或成人血的血小板贫乏血浆在暴露于胆红素和/或光后没有显著变化，黄疸新生儿治疗前后的血浆也没有任何变化。尽管本研究中的光照暴露时间较短，但结果表明，临床使用的较低辐照度水平对血小板无害，且辐照度高三倍的研究结果几乎没有临床相关性。
