Satake K, Kitamura T, Ishikawa T, Mukai R, Yoshimoto T, Chung Y S, Umeyama K
J Surg Oncol. 1981;17(3):225-33. doi: 10.1002/jso.2930170305.
A comparative study of carcinoembryonic antigen (CEA) and beta 2-microglobulin in serum was made by radioimmunoassay in 121 patients with gastric disease. There was no statistical difference in serum CEA and beta 2-microglobulin in patients with benign gastric disease, early gastric carcinoma, and advanced gastric carcinoma. However, CEA levels in patients with advanced gastric carcinoma were higher than those in benign gastric disease and in early gastric carcinoma but beta 2-microglobulin did not show and differences. Furthermore, after total removal of the tumor, the elevated CEA levels decreased but beta 2-microglobulin remained unchanged. We concluded that CEA appeared to predict tumor behavior more accurately in patients with gastric carcinoma than beta 2-microglobulin.
采用放射免疫分析法对121例胃病患者的血清癌胚抗原（CEA）和β2-微球蛋白进行了对比研究。良性胃病患者、早期胃癌患者和进展期胃癌患者的血清CEA和β2-微球蛋白水平无统计学差异。然而，进展期胃癌患者的CEA水平高于良性胃病患者和早期胃癌患者，但β2-微球蛋白水平无差异。此外，肿瘤完全切除后，升高的CEA水平下降，但β2-微球蛋白水平保持不变。我们得出结论，在胃癌患者中，CEA似乎比β2-微球蛋白更能准确预测肿瘤行为。
