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小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。V. IgD阳性和IgD阴性记忆B细胞均可传递高亲和力二次抗体应答。

The relationship between surface immunoglobulin isotype and the immune function of murine B lymphocytes. V. High affinity secondary antibody responses are transferred by both IgD-positive and IgD-negative memory B cells.

作者信息

Lafrenz D, Strober S, Vitetta E

出版信息

J Immunol. 1981 Sep;127(3):867-72.

PMID:6167629
Abstract

We examined the adoptive secondary anti-DNP responses restored by surface IgD+ and IgD- memory B cells. Several parameters that might affect the affinity and magnitude of the adoptive responses were studied: 1) time after priming of cell donors, 2) source of anti-IgD antibodies used for immunofluorescent cell staining, 3) adjuvant used for priming, 4) carrier protein used for priming, 5) amount of antigen used for the challenge of adoptive hosts, and 6) the strain of ice used as donors and recipients. In contrast to previous reports, the present results demonstrate that the selection of cells with high affinity antigen receptors can occur to the same extent in both the delta + and delta - memory cell pools. This suggests that the loss of surface IgD is not a necessary intermediate stage in the maturation of memory B cells.

摘要

我们检测了由表面IgD⁺和IgD⁻记忆B细胞恢复的过继性二次抗DNP反应。研究了几个可能影响过继性反应亲和力和强度的参数:1)细胞供体初次免疫后的时间,2)用于免疫荧光细胞染色的抗IgD抗体来源,3)初次免疫所用佐剂,4)初次免疫所用载体蛋白,5)用于攻击过继宿主的抗原量,以及6)用作供体和受体的小鼠品系。与之前的报道相反,目前的结果表明,在δ⁺和δ⁻记忆细胞库中,具有高亲和力抗原受体的细胞选择可以在相同程度上发生。这表明表面IgD的缺失不是记忆B细胞成熟过程中必要的中间阶段。

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