体外通过单克隆抗体诱导H-Y免疫细胞毒性T细胞过程中识别的H-2决定簇分析
Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro.
作者信息
Brenan M, Müllbacher A
出版信息
J Exp Med. 1981 Aug 1;154(2):563-8. doi: 10.1084/jem.154.2.563.
Abstract
Monoclonal antibodies directed to the D region of H-2(k) when present during in vitro culture inhibit the generation of CBA/H and C3H.H-2(o) H-Y-immune cytotoxic T cells . Monoclonal antibodies directed to the I-A(k) and I-E(k) region specifically inhibited induction of CBA/H H-Y-immune cytotoxic T cells only when they were present simultaneously in culture. These findings show T helper cell requirement for CBA/H H-Y-immune cytotoxic T cell induction, and suggest that two I region-coded restriction antigens for T helper cells are involved.
摘要
在体外培养期间存在时，针对H-2(k) D区的单克隆抗体可抑制CBA/H和C3H.H-2(o) H-Y免疫细胞毒性T细胞的生成。仅当针对I-A(k)和I-E(k)区的单克隆抗体同时存在于培养物中时，它们才特异性抑制CBA/H H-Y免疫细胞毒性T细胞的诱导。这些发现表明CBA/H H-Y免疫细胞毒性T细胞诱导需要T辅助细胞，并提示涉及两种I区编码的T辅助细胞限制性抗原。
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Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro.体外通过单克隆抗体诱导H-Y免疫细胞毒性T细胞过程中识别的H-2决定簇分析
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本文引用的文献
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Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice.利用单克隆抗体对小鼠主要组织相容性复合体和Qa/TL区域所控制抗原进行的精细特异性分析。
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