Analysis of the cytotoxic T cell response to H-Y in CBA/H mice.

The dose response, kinetics, and target cell specificity of the H-Y immune Tc-cell response of fp-primed CBA/H mice was analyzed. Non-MHC genes were shown to influence responsiveness in fp-primed H-2k strains of mice. The possibility that dominant T-suppressor cells mask responsiveness in i.p. primed CBA/H mice was not confirmed in mixing experiments. Female spleen-adherent cells injected with male spleen cells i.p. elicited H-Y immune Tc-cell responses.