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在经碘脱氧尿苷（IdUrd）处理并被诱导表达内源性逆转录病毒的小鼠细胞中，干扰素介导的蛋白激酶

Interferon-mediated protein kinase in mouse cells treated with iododeoxyuridine (IdUrd) and induced to express endogenous retroviruses.

作者信息

Hovanessian A G, Barré-Sinoussi F, Montagnier L

出版信息

J Gen Virol. 1981 Jan;52(Pt 1):199-204. doi: 10.1099/0022-1317-52-1-199.

DOI:10.1099/0022-1317-52-1-199
PMID:6167665
Abstract

Treatment of K/Balb cells with IdUrd leads to the expression of endogenous virus and interferon is formed which subsequently can suppress the release of virus into the medium. Under these conditions, a protein kinase activity capable of phosphorylating an endogenous polypeptide of apparent mol. wt. 67000 is detected. This kinase activity is analogous to that induced in K/Balb cells treated with exogenous interferon. The induction of the protein kinase activity in IdUrd-treated K/Balb cells can be blocked by anti-interferon serum, thus providing evidence for the presence and action of interferon.

摘要

用碘苷处理K/Balb细胞会导致内源性病毒的表达，并形成干扰素，随后干扰素可抑制病毒释放到培养基中。在这些条件下，检测到一种能够磷酸化表观分子量为67000的内源性多肽的蛋白激酶活性。这种激酶活性类似于用外源性干扰素处理的K/Balb细胞中诱导产生的激酶活性。抗干扰素血清可阻断碘苷处理的K/Balb细胞中蛋白激酶活性的诱导，从而为干扰素的存在和作用提供了证据。

相似文献

1
Interferon-mediated protein kinase in mouse cells treated with iododeoxyuridine (IdUrd) and induced to express endogenous retroviruses.在经碘脱氧尿苷（IdUrd）处理并被诱导表达内源性逆转录病毒的小鼠细胞中，干扰素介导的蛋白激酶
J Gen Virol. 1981 Jan;52(Pt 1):199-204. doi: 10.1099/0022-1317-52-1-199.
2
Enhancement of retrovirus production by anti-interferon serum.抗干扰素血清增强逆转录病毒的产生
Ann Microbiol (Paris). 1979 Oct;130B(3):349-62.
3
Induction of poly(I):poly(C)-binding 50 K protein and 2',5'-oligoadenylate synthetase in interferon-treated mouse L929 cells.在经干扰素处理的小鼠L929细胞中诱导多聚（I）：多聚（C）结合50K蛋白和2'，5'-寡腺苷酸合成酶。
J Biochem. 1980 Jul;88(1):159-66.
4
Induction of anti-viral activity and specific enzymes in cell-lines derived from interferon-resistant, thymidine kinase deficient mouse L-929 cells.在源自抗干扰素、胸苷激酶缺陷型小鼠L-929细胞的细胞系中诱导抗病毒活性和特异性酶。
Prog Clin Biol Res. 1985;202:325-32.
5
Molecular mechanisms of interferon action.
Med Pediatr Oncol. 1981;9(1):83-8.
6
Protein kinase activity and the natural occurrence of 2-5A in interferon-treated EMC virus-infected L-cells.蛋白质激酶活性以及2-5A在经干扰素处理的脑心肌炎病毒感染的L细胞中的自然存在情况。
Ann N Y Acad Sci. 1980;350:448-58. doi: 10.1111/j.1749-6632.1980.tb20648.x.
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Human leukocyte interferon induces 2', 5'-oligo (A) polymerase and protein kinase.人白细胞干扰素可诱导2',5'-寡聚（A）聚合酶和蛋白激酶。
Virology. 1980 Mar;101(2):540-4. doi: 10.1016/0042-6822(80)90470-5.
8
Lack of systematic correlation between the interferon mediated antiviral state and the levels of 2-5A synthetase and protein kinase in three different types of murine cells.在三种不同类型的小鼠细胞中，干扰素介导的抗病毒状态与2-5A合成酶和蛋白激酶水平之间缺乏系统性关联。
J Interferon Res. 1981 Feb;1(2):179-90. doi: 10.1089/jir.1981.1.179.
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Isolation of thioguanine resistant variants of K-BALB cells non-inducible for type C viruses by 5-iododeoxyuridine.通过5-碘脱氧尿苷分离对C型病毒无诱导性的K-BALB细胞的硫鸟嘌呤抗性变体。
J Gen Virol. 1978 Mar;38(3):419-29. doi: 10.1099/0022-1317-38-3-419.
10
Antiviral response and induction of specific proteins in cells treated with immune T (type II) interferon analogous to that from viral interferon (type I)-treated cells.用免疫T（II型）干扰素处理的细胞中的抗病毒反应和特定蛋白质的诱导，类似于用病毒干扰素（I型）处理的细胞。
Virology. 1980 Jul 15;104(1):195-204. doi: 10.1016/0042-6822(80)90377-3.

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